RNAi in cell nuclei: potential for a new layer of biological regulation and a new strategy for therapeutic discovery

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FIGURE 1.
FIGURE 1.

Model showing a potential mechanism for transcriptional activation or repression. The RNA:AGO:TNRC6 complex binds at a promoter to a nascent transcript (not directly to chromosomal DNA) and alters the mix of proteins necessary for gene activation or repression.

This Article

  1. Published in Advance January 19, 2023, doi: 10.1261/rna.079500.122 RNA 29: 415-422

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