Acyclic (S)-glycol nucleic acid (S-GNA) modification of siRNAs improves the safety of RNAi therapeutics while maintaining potency

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FIGURE 7.
FIGURE 7.

Position-dependent effect of (S)-GNA on in vitro potency of siRNA-mediated silencing of the Ttr gene in an in vitro assay; antisense (guide) strand on left and sense (passenger) strand on right.

This Article

  1. Published in Advance February 1, 2023, doi: 10.1261/rna.079526.122 RNA 29: 402-414

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