Acyclic (S)-glycol nucleic acid (S-GNA) modification of siRNAs improves the safety of RNAi therapeutics while maintaining potency

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FIGURE 6.
FIGURE 6.

(A) Superimposed (S)-GNA T and TNA T inside RNA, demonstrating that GNA with the thymine base flipped (i.e., matching the TNA base orientation) results in a clash with the adjacent base (suboptimal stacking). (B) Crystal structure of RNA with an incorporated (S)-GNA T residue that displays the rotated orientation of the thymine base.

This Article

  1. Published in Advance February 1, 2023, doi: 10.1261/rna.079526.122 RNA 29: 402-414

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