Acyclic (S)-glycol nucleic acid (S-GNA) modification of siRNAs improves the safety of RNAi therapeutics while maintaining potency

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FIGURE 4.
FIGURE 4.

Crystal structures of (S)-GNA octamer duplexes, PDB ID 2JJA (left) and PDB ID 2XC6 (right), viewed across the two grooves (top) and along the helical axis (bottom).

This Article

  1. Published in Advance February 1, 2023, doi: 10.1261/rna.079526.122 RNA 29: 402-414

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