Acyclic (S)-glycol nucleic acid (S-GNA) modification of siRNAs improves the safety of RNAi therapeutics while maintaining potency

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FIGURE 1.
FIGURE 1.

(A) Structures of building blocks used in nucleic acid therapeutics. (B) Schematics of lipid nanoparticle (LNP) formulations and GalNAc conjugate.

This Article

  1. Published in Advance February 1, 2023, doi: 10.1261/rna.079526.122 RNA 29: 402-414

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