DNMT1 inhibition by pUG-fold quadruplex RNA

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FIGURE 4.
FIGURE 4.

DNMT1 binds to GU repeats in a length-dependent manner. (A) Binding curves of (GU)20 in KCl and LiCl (blue and red, respectively) and (GU)30 in KCl and LiCl (light blue and orange, respectively). Corresponding EMSAs are shown in Supplemental Figure S5. (B) Binding curves of (AC)20 and (AC)30 with DNMT1 (dark green and light green, respectively). Corresponding EMSAs are shown in Supplemental Figure S5. In both panels, points represent mean values and error bars represent SD for n = 3 replicates.

This Article

  1. Published in Advance December 27, 2022, doi: 10.1261/rna.079479.122 RNA 29: 346-360

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