Specific mechanisms of translation initiation in higher eukaryotes: the eIF4G2 story

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FIGURE 3.
FIGURE 3.

Unconventional cap-dependent initiation modes that involve eIF4G2. (A) PARN-dependent initiation. The miRNA induces mRNA deadenylation by PARN, which also binds to the m7G-cap and is found in the complex with AGO2, FXR1, and eIF4G2. Presumably, eIF4G2 facilitates further scanning. (B) eIF3d-dependent initiation. eIF3 interacts with the special structure in the 5′ UTR of mRNA; the eIF3d subunit specifically binds the m7G-cap and eIF4G2, which participates in subsequent scanning.

This Article

  1. Published in Advance December 14, 2022, doi: 10.1261/rna.079462.122 RNA 29: 282-299

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