Full-length predicted structures of KREL1 and KREPA2. (A) Full-length Alphafold structure prediction of KREL1. The structure has two domains: NTD and CTD, which are connected by a variable loop region (VLR). The four-α helices of the CTD are labeled. A schematic of the mutations made on KREL1 is shown below the structure. The black arrows represent the site of the truncations and the Δ represents the internal helix deletion. (B) Full-length Alphafold structure prediction of KREPA2. The structure has an OB-fold domain, two ZnF domains and one α helix. A schematic of the mutations made on KREPA2 is shown below the structure. The black arrow at 484 represents the truncation made for the deletion of the OB-fold, the gray arrows represent the alanine substitutions of the cysteine residues of both ZnFs and Δ represents the internal deletion of the αH1.
