FIGURE 3.
Depletion and enrichment on chromosome scale from hiPSC-CM. Fifty percent of pores on a MinION flow cell were used for NS and 50% for AS. Reads mapping to Chromosome 11 were subjected to AS in depletion, enrichment or reverse enrichment (depletion of all chromosomes except for Chromosome 11) mode. (A–C) Stack plot of reads per chromosome split according to the AS decision for depletion (A), enrichment (B), and reverse enrichment (C) of Chromosome 11. (D) Enrichment factor per sequenced bases for every chromosome calculated for the three AS modes from reads split into “normal sequencing” and “total reads from adaptive sampling.”
