(A) Prevalence of the s2m G15U mutation (dashed) and Delta variant (solid) within total reported SARS-CoV-2 cases in the United States (blue), United Kingdom (orange), and India (purple). (B) The s2m G15U mutant (purple dashed line, square markers) rose in prevalence before the rise of the Delta variant (purple solid line). Kappa (pink solid line) was also found to maintain the s2m G15U mutation and comprised of most cases within India that were not accounted for with Delta. The combination of the Kappa and Delta variants’ prevalence (green solid line) is tightly correlated with the s2m G15U mutant, mirroring trends later observed as Delta spread worldwide.
