Cover image

tRNA synthetase viral tRNA-mimic complex (PDB id: 7SC6; Bonilla SL, Sherlock ME, MacFadden A, Kieft JS. 2021. A viral RNA hijacks host machinery using dynamic conformational changes of a tRNA-like structure. Science 374: 955–960). The cryo-EM structure of the viral tRNA-mimic from brome mosaic virus bound to the Tyrosyl-tRNA synthetase (TyrRS) of the virus host (Phaseolus vulgaris) is shown. The RNA undergoes large conformational rearrangements to bind TyrRS in a form that differs substantially from that of tRNA. Viral tRNA-mimic backbone is displayed as a red ribbon, with block bases in NDB colors: A—red, C—yellow, G—green, U—cyan; TyrRS enzyme is displayed as a gold ribbon. Cover image provided by the Nucleic Acid Database (NDB)/Nucleic Acid Knowledgebase (NAKB; nakb.org). Image generated using DSSR and PyMOL (Lu XJ. 2020. Nucleic Acids Res 48: e74)