The Trypanosoma brucei RNA-binding protein DRBD18 ensures correct mRNA trans splicing and polyadenylation patterns

Effects of DRBD18 depletion show chromosomal clustering. The effects of DRBD18 depletion (log₂ fold change) for unique genes (without paralogs) were plotted as orange bars according to the order of the genes on the chromosomes (positions not to scale). Start sites according to histone modifications (Siegel et al. 2009) and transcript orientation are upward blue bars, and stop sites are downward bars. Neighboring smaller bars indicate the orientation. The scale of the y-axis has been truncated so that all effects greater than 2.8-fold are shown as log₂(1.5). Black horizontal arrows indicate the directions of selected affected transcription units.