Comparison of CpG- and UpA-mediated restriction of RNA virus replication in mammalian and avian cells and investigation of potential ZAP-mediated shaping of host transcriptome compositions

(Downloading may take up to 30 seconds. If the slide opens in your browser, select File -> Save As to save it.)

Click on image to view larger version.

FIGURE 7.
FIGURE 7.

(A) CpG and (B) UpA representation in mammalian interferon genes. Comparison of dinucleotide representations of IFN-α, IFN-β, and IFN-γ in mammalian species with the bulk human mRNA transcriptome (IFN gene accession numbers and host species are listed in Supplemental Data Table S8). Differences in values over defined G + C content ranges specific for each IFN gene class were analyzed using the independent samples t-test.

This Article

  1. Published in Advance June 8, 2022, doi: 10.1261/rna.079102.122 RNA 28: 1089-1109

Current Issue

  1. July 2026, 32 (7)
  1. Current Issue
  1. Alert me to new issues of RNA