Ligands with polyfluorophenyl moieties promote a local structural rearrangement in the Spinach2 and Broccoli aptamers that increases ligand affinities

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FIGURE 3.
FIGURE 3.

Influence of the position of the phenyl group relative to the imido nitrogen of DFHBI. (A) The predicted 3D models of two DFHBI derivatives with either a one carbon link to the phenyl group (MFP-DFHBI) or a two carbon link (compound 5). (B) Affinities (Kas) in buffer SX of compounds with benzyl or phenethyl extensions from the imido nitrogen.

This Article

  1. Published in Advance March 29, 2022, doi: 10.1261/rna.079005.121 RNA 28: 865-877

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