Ligands with polyfluorophenyl moieties promote a local structural rearrangement in the Spinach2 and Broccoli aptamers that increases ligand affinities

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FIGURE 1.
FIGURE 1.

DFHBI imido-N extension library. (A) Positions of the gateway A (stippled) and the DFHBI methyl group (filled) SPN2 crystal structure. (B) Overview of the synthesis protocol for compounds. (C–G) Chemical structures of the synthesized DFHBI derivatives. Letter abbreviations are defined in Supplemental Table S1.

This Article

  1. Published in Advance March 29, 2022, doi: 10.1261/rna.079005.121 RNA 28: 865-877

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