The modifying enzyme Tsr3 establishes the hierarchy of Rio kinase binding in 40S ribosome assembly

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FIGURE 7.
FIGURE 7.

Tsr3 coordinates the activity of Rio1 and Rio2. Schematic model showing how Tsr3 coordinates and separates the activities of Rio2 and Rio1. Rio2 binding to pre-40S blocks premature binding of Tsr3. Once bound though, Tsr3 blocks rebinding of Rio2 as well as premature binding of Rio1 at its functional site. Its initial recruitment adjacent to h44 is unaffected by Tsr3 binding.

This Article

  1. Published in Advance January 14, 2022, doi: 10.1261/rna.078994.121 RNA 28: 568-582

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