Alternative splicing regulation of membrane trafficking genes during myogenesis

Membrane trafficking genes contain putative PTBP1 and QKI binding motifs in and around the alternatively spliced regions. (A,B) Schematic of the mechanism of PTBP1 (A) and QKI (B) regulation of alternative splicing. (C,D) Bioinformatic motif analysis for membrane trafficking genes for PTBP1 (C) and QKI (D). PTBP1 motifs are indicated by black triangles and QKI motifs by red triangles. Analysis was performed using ten PTBP1 motifs and ten QKI motifs. Exons and introns are scaled according to size. Up to 500 nt of the upstream intron and downstream intron was used for analysis.