Widespread genetic heterogeneity of human ribosomal RNA genes

Annotation of variants on 28S rRNA structure. (A) Variant density on the secondary structure diagram of 28S rRNA. Nucleotides are color-labeled by the variant density value. (B) Variants of 28S rRNA (shown in blue) are shown on the 3D structure model (PDB 4V6X). Nucleotides are color-labeled by the variant density value as in A. High variant density expansion segments (ES) ES7L and ES27L are indicated. Images were generated with RiboVision.