Conserved and transcript-specific functions of the RESC factors, RESC13 and RESC14, in kinetoplastid RNA editing

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FIGURE 3.
FIGURE 3.

RESC13 and RESC14 have both conserved and transcript-specific effects on junction length. The number of sequences for each junction length were quantified across the whole population of partially edited sequences for A6, COIII, and RPS12 transcripts, in uninduced, RESC13 RNAi- induced (top, red) and RESC14 RNAi-induced (bottom, cyan) cells. Reads were normalized to 100,000. Junction lengths are divided into 11 categories based on the number of editing sites spanned: starting with length 0, then combining spans of 10 editing sites from lengths 1–90, followed by lengths 91 and above. Black asterisks denote junction lengths that were significantly increased in the RNAi samples relative to the uninduced, where blue asterisks denote junction lengths that were significantly decreased in the RNAi samples relative to the uninduced. (*) Padj < 0.05, (**) Padj < 0.01, (***) Padj < 0.001, (****) Padj < 0.0001. The insets for A6 mRNA show a close-up of the values for the longer junctions.

This Article

  1. RNA 28: 1496-1508