RESC13 and RESC14 functions in gRNA utilization and exchange. A6 (A) and COIII (B) edited mRNA sequences with the exacerbated pause sites (EPS; diamonds) that arise upon RESC13 (red shades) and RESC14 (cyan shades) depletion. The average number of sequences found in the two induced replicates is represented by different diamond shading, and the fold change of the induced samples to their uninduced controls are represented by different diamond sizes. The black dots above the diamonds represent EPS at gRNA ends. Black bars below the sequences represent cognate gRNAs as reported by Koslowsky et al. (2014), which are numbered in the 3′ to 5′ direction along the mRNA. gRNA anchors are depicted as the black bold lines while the gray regions denote range of variation of gRNA lengths across members of the same gRNA class. The uppercase U's are encoded in the mitochondrial genome, while the lowercase u's represent inserted uridines during the editing process. Asterisks (*) denote sites where encoded uridines were deleted during the editing process. Underscores are shown for clarity in stretches of unedited sequence to align editing site numbers with the correct editing site. The stop codon is underlined.
