Replication of alphaviruses requires a pseudoknot that involves the poly(A) tail

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FIGURE 5.
FIGURE 5.

(A) Putative base triples in the SINV pseudoknot, adopting either a KSHV-like conformation (top) or a human telomerase pseudoknot-like conformation (bottom). Red dotted lines indicate Hoogsteen base-pairing of U with an AU base pair. (B) Testing the KSHV-like pseudoknot conformation by mutating a putative base triple between U−3, A+13, and U−12 using the SINV replicon.

This Article

  1. Published in Advance July 29, 2022, doi: 10.1261/rna.079243.122 RNA 28: 1348-1358

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