Replication of alphaviruses requires a pseudoknot that involves the poly(A) tail

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FIGURE 10.
FIGURE 10.

Comparison of alphavirus and telomerase pseudoknots. (A) Similarities between SINV and human and tetrahymena telomerase pseudoknots. Green dotted lines indicate A-minor interactions, red dotted lines indicate Hoogsteen base pairs, and black dashes Watson–Crick base pairs. The interactions in T. pigmentosa are drawn by analogy to the T. thermophila pseudoknot (Cash and Feigon 2017). (B) Detailed models of the MIDV and SINV pseudoknots are drawn to resemble the human telomerase pseudoknot (Theimer et al. 2005).

This Article

  1. RNA 28: 1348-1358