Expansion and functional analysis of the SR-related protein family across the domains of life

New SR-related RBPs localize to nuclear speckles and participate in mRNA processing. (A) Percentage of proteins in each category with experimentally verified localization to specific subcellular compartments. (B) Predicted Pfam annotations assigned to available proteins from each category. (C) Percentage of proteins with literature-derived function annotations assigned to each RBP. (D) Percentage of proteins assigned to each RNA target category, derived from a literature-based consensus of the type of RNA bound by each RBP.