RS domains of human SR/SR-related proteins are frequently affected across isoforms. (A) Representative examples of sequence variation effects on RS domains among SR-related protein isoform sets based on: (1) whether all isoforms in the set contain an RS domain, and (2) whether all extant RS domains for an isoform set perfectly match each other. For these two criteria, (+) indicates isoform sets for which the criterium is true, whereas (−) indicates isoform sets for which the criterium is false. (B) Frequency analysis of sequence variation effects on human SR/SR-related protein isoform sets. (C) Proportion of isoforms that contain an RS domain and proportion of existing RS domains that perfectly align for proteins with RS domains that do not perfectly match (24 proteins in panel B). (D) Proportion of isoforms that contain an RS domain for all isoforms where the existing RS domains perfectly align (71 proteins in panel B).
