Potential biological importance of translated lncRNAs in neural development, differentiation, and disease. (A) Percentage of translated lncRNA genes and all lncRNA genes, which exhibit dynamic expression during human development according to lncExpDB (Sarropoulos et al. 2019). (B) Percentage of the dynamically expressed, translated lncRNAs, which show dynamic expression in each organ, for total and translated lncRNA populations, according to LncExpDB (Sarropoulos et al. 2019). (C) Proportion of translated lncRNAs, which exhibit differential expression during differentiation of SH-SY5Y cells. (D) GO terms associated with changes in RNA-seq levels upon siRNA knockdown of three of the translated lncRNAs (LINC01116, FGD5-AS1, and TUG1) performed by FANTOM6 in human dermal fibroblasts. (E) Percentage of translated lncRNA genes found to be associated with neuronal diseases and disorders according to lncRNADisease, Differential Expression Atlas, Cancer RNA-Seq Nexus, Malacards.
