Cytoplasmic long noncoding RNAs are differentially regulated and translated during human neuronal differentiation

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FIGURE 5.
FIGURE 5.

Translated lncRNA-smORFs exhibit sequence conservation in great apes. (A) Phylogram with lncRNA-smORFs for which evidence of sequence conservation was found represented as circles, colored according to how sequence conservation was identified. Phylogram built in iTOL (Letunic and Bork 2011) using data from TimeTree (Kumar et al. 2017), scale in 10 MYA. (B) Portion of human ENST00000442428 lncRNA nt alignment with gorilla and orangutan nt sequences, showing the smORF. Alignment built in ClustalOmega (Sievers et al. 2011) displayed in JalView (Waterhouse et al. 2009).

This Article

  1. Published in Advance June 30, 2021, doi: 10.1261/rna.078782.121 RNA 27: 1082-1101

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