Regulation of closely juxtaposed proto-oncogene c-fms and HMGXB3 gene expression by mRNA 3′ end polymorphism in breast cancer cells

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FIGURE 8.
FIGURE 8.

Termination of convergent transcription elongation. (A) Transcription elongation complexes collide in the convergent gene pairs and terminate transcription. (B) Differential rate of transcription elongation between the convergent gene pairs results in the 3′ end polymorphism. (C) Transcriptional bypass also generates the 3′ end polymorphism. mRNA is depicted with the poly(An) tail. Poly(A) signal sequences are shown in HMGXB3 mRNA (5240–5245) and c-fms mRNA (3963–3968).

This Article

  1. Published in Advance June 21, 2021, doi: 10.1261/rna.078749.121 RNA 27: 1068-1081

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