Secondary structure-related features in association with editing frequency. (A) Distribution of different types of overall secondary structure in editing sites. Cloop, Cstem, and Ctail are three subtypes of canonical secondary structure based on the location of the edited cytidine. (B) Association between type of secondary structure and editing frequency. (C) Distribution of the mooring sequence location in editing sites. “Other” refers to mooring sequences located in tail or stem/loop and not part of the main stem–loop structure. (D) Association of mooring sequence location with editing frequency. (E) Association between ratio of main stem–loop bases to total bases count and editing frequency. (F) Association of the 5′ free tail length with editing frequency. (*) P < 0.05; (**) P < 0.001. (r) Pearson correlation coefficient.
