Characteristics of murine APOBEC1-mediated C-to-U mRNA editing sites. (A) Schematic presentation of mRNA target, chromosomal editing location, and editing sites considered. Each mRNA target could be edited at one or more chromosomal location(s) (blue boxes). Each editing location could be edited in one or more tissues, giving rise to one or more editing site(s) per location (green boxes). Editing site(s) of each mRNA target are the sum of editing sites from all editing locations reported for that target. (B) Examples of canonical (Apob chr12: 8014860, top) and two types of noncanonical (Kctd12 chr14: 103379573 and Dcn chr10: 96980535) secondary structures. (C) Distribution of number of chromosomal editing location(s), or targeted cytidine(s), per mRNA target. (D) Distribution of number of total editing sites per mRNA target considering all chromosomal location(s) edited at different tissue(s). (E) Distribution of location of editing sites within gene structure.
