Cover image

Manganese riboswitch from Xanthmonas oryzae (PDB id: 6N2V; Suddala KC, Price IR, Dandpat SS, Janeček M, Kührová P, Šponer J, Banáš P, Ke A, Walter NG. 2019. Local-to-global signal transduction at the core of a Mn²⁺ sensing riboswitch. Nat Commun 10: 4304). Bacterial manganese riboswitches control the expression of Mn²⁺ homeostasis genes. Using FRET, it was shown that an extended 4-way-junction samples transient docked states in the presence of Mg²⁺ but can only dock stably upon addition of submillimolar Mn²⁺. RNA backbone is displayed as a red ribbon; block bases use NDB colors: A—red, C—yellow, G—green, U—cyan. Bound cations are shown as spheres: Mg²⁺—orange, Mn²⁺—purple, Sr²⁺—yellow. Cover image provided by the Nucleic Acid Database (ndbserver.rutgers.edu). Image generated using DSSR and PyMOL (Lu XJ. 2020. Nucleic Acids Res 48: e74).