Disease-associated mutations in mitochondrial precursor tRNAs affect binding, m1R9 methylation, and tRNA processing by mtRNase P

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FIGURE 4.
FIGURE 4.

Disease-associated tRNA mutations alter the structure of pre-tRNAs. (A) Representative UV melting profile curves for the wild-type and mutant (mt)pre-tRNAIle variants. (B,C) Representative UV melting profile curves of wild-type and mutant (mt)pre-tRNALeu(UUR)s. (D) Representative UV melting profile curves of wild-type and mutant (mt)pre-tRNAMets.

This Article

  1. Published in Advance December 30, 2020, doi: 10.1261/rna.077198.120 RNA 27: 420-432

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