FIGURE 8.
PrP Aptamer. (A) Cartoon representation of the three-dimensional structure of an anti-PrP aptamer bound to a small peptide from the soluble isoform of the protein (PDB:2RSK; Mashima et al. 2013). The PrP-derived peptide is highlighted by its molecular surface. Dashed red line denotes the dimer interface of the aptamer. Adenosines that extend the interfacial G-quartet into a hexad are colored magenta. (B) Schematic of the PrP aptamer illustrating the canonical RNA G4 stereochemistry.
