The emerging structural complexity of G-quadruplex RNAs

The Mango family of fluorescence turn-on RNA aptamers. (A) Cartoon representation of the quadruplex portion of the cocrystal structure of Mango-I bound to the TO1-Biotin fluorophore (PDB: 5V3F; Trachman et al. 2017). (B) Schematic of Mango-I G4. (C) Schematic of the Mango-II G4 (PDB:6C63; Trachman et al. 2018). (D) Cartoon representation of the quadruplex portion of the cocrystal structure of Mango-III bound to TO1-biotin (PDB:6E8T; Trachman et al. 2019). (E) Schematic of the Mango-III G4. (F) Schematic of the Mango-IV G4 (PDB:6V9B; Trachman et al. 2020).