The emerging structural complexity of G-quadruplex RNAs

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FIGURE 5.
FIGURE 5.

The Corn fluorescence turn-on aptamer. (A) Cartoon representation of the Corn homodimer with the fluorophore DFHO bound at the dimer interface (PDB:5BJO; Warner et al. 2017). Red arrows point to the two mixed-sequenced quartets. (B) Schematic of the quadruplex element of Corn. (C) Detail of the A•U•A•U quartet of Corn. Water molecules and K+ depicted as red and purple spheres, respectively. For structure determination U17 was replaced with 5-iodouracil (Warner et al. 2017). Subsequent Corn structures, containing RNA lacking halogens, showed the same conformation of the quartet (Sjekloća and Ferré-D'Amaré 2019). (D) Detail of the G•C•G•C quartet of Corn.

This Article

  1. Published in Advance January 22, 2021, doi: 10.1261/rna.078238.120 RNA 27: 390-402

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