FIGURE 5.
Approaches for the detection of RNA modifications. The figure presents the experimental approaches to the detection of RNA modifications, one per column and left to right: (A) Detection of nonrandom mismatch signatures (RT-signature), (B) capture with antibody, (C) pretreatment with chemical reagents, (D) capture with modification-related enzymes, and (E) detection of modification-specific signals using the Oxford Nanopore Technologies (ONT) platform (ONT-signature). Each column includes the approach schema, with rows below it indicating the approach name, its detection principle, output type, and techniques implementing that approach.
