CtIP-mediated alternative mRNA splicing fine-tunes the DNA damage response

PIF1 splicing variants affect the recruitment of DDR factors. (A) Average number of 53BP1 foci per cell upon exposure to 10 Gy of IR in cells transfected with the indicated vectors relative to control cells. The average and standard deviation of three independent experiments is shown. Statistical significance was calculated using an ANOVA test. (*) P < 0.05. (B) Same as A but for RIF1 foci. (C) Same as A but for RAD51 foci.