Mitochondrial misreading in skeletal muscle accelerates metabolic aging and confers lipid accumulation and increased inflammation

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FIGURE 3.
FIGURE 3.

Mrps5 V338Y mutation-specific changes in 19-mo-old animals. (A) Heatmap of metabolites associated with the group of 19 mo Mrps5 V338Y animals (Students's t-test for 19 mo Mrps5 V338Y mice and 19 mo Mrps5 wild-type animals; P < 0.05). (B) Model of metabolite pathways, including enzymes and the electron carrying coenzymes, altered in the Mrps5 V338Y animals in contrast to wild-type at 19 mo age (PPP) pentose phosphate pathway, (OAA) oxaloacetate, (G3P) glycerol 3-phosphate, (LPA) lysophosphatidic acid, (PA) phosphatidic acid, (DAG) diacylglycerol, (TAG) triacylglycerol.

This Article

  1. Published in Advance December 1, 2020, doi: 10.1261/rna.077347.120 RNA 27: 265-272

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