Mitochondrial misreading in skeletal muscle accelerates metabolic aging and confers lipid accumulation and increased inflammation

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FIGURE 1.
FIGURE 1.

Muscle transcriptome analysis of mice. (A) Gene enrichment analysis comparing 19 mo MrpS5 WT and MrpS5 V338Y mutant mice; terms and significance for up-regulated gene transcripts, adjusted P-values are shown. (B) Expression heatmap of up-regulated genes enriched in GO term “Inflammatory process” across 3 mo and 19 mo muscle samples.

This Article

  1. Published in Advance December 1, 2020, doi: 10.1261/rna.077347.120 RNA 27: 265-272

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