An open interface in the pre-80S ribosome coordinated by ribosome assembly factors Tsr1 and Dim1 enables temporal regulation of Fap7

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FIGURE 1.
FIGURE 1.

80S-like ribosomes join via an immature interface. (A) In 80S-like preribosomes, the space between the subunits is expanded. Mature 80S/80S-like identifies each structure (bold italics). 60S/40S/pre-40S identify each subunit (bold). Structural elements are identified in each subunit (lower case). 60S is light blue and 40S and pre-40S are yellow. (B) Overall structure of 80S-like ribosomes. Dim1 is dark blue and Tsr1 is green. (C) The pre-40S interface has only the AFs Tsr1 (green) and Dim1 (blue) bound. The structure is viewed from the point of view of the 60S subunit.

This Article

  1. Published in Advance November 20, 2020, doi: 10.1261/rna.077610.120 RNA 27: 221-233

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