Posttranscriptional modifications at the 37th position in the anticodon stem–loop of tRNA: structural insights from MD simulations

(A) Probability distribution in the location of the side chain in the yW hypermodified nucleobase at the 37th position in E. coli tRNA. (B) Overlays of yW and o²yW modified nucleobases in tRNA with respect to the nucleobase ring for structures taken at 5 ns intervals over the MD simulations. (C) Average structural deviation of anticodon nucleotides (RMSF, Å) over the MD simulations with respect to the initial structure for each yW modified tRNA compared to unmodified G-tRNA.