Posttranscriptional modifications at the 37th position in the anticodon stem–loop of tRNA: structural insights from MD simulations

(A) Stacking interactions between base 37 and neighboring nucleobases in the anticodon loop of yeast tRNA and (B) hydrogen-bonding interactions (with occupancies) between bases 37 and 33 throughout the MD simulations for unmodified, m¹G and yW-modified yeast tRNAs. (C) consensus secondary structures of the anticodon stem–loop region in unmodified and modified tRNA, with the solid red circle representing the nucleotide at the 37th position of yeast tRNA. The color scheme shows the probability distribution of the interactions within the cluster.