Mechanistic analysis of the enhanced RNAi activity by 6-mCEPh-purine at the 5′ end of the siRNA guide strand

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FIGURE 8.
FIGURE 8.

A model for the molecular mechanism by which 6-mCEPh-purine enhances the RNAi activity. 6-mCEPh-purine modification improves the formation of mature RISC in two different ways: (1) 6-mCEPh-purine helps the guide strand selection. (2) 6-mCEPh-purine increases the stability of mature RISC after passenger strand ejection.

This Article

  1. Published in Advance November 11, 2020, doi: 10.1261/rna.073775.119 RNA 27: 151-162

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