Editing differences between cortical regions and neuronal subtypes. (A) Distribution of global editing index (GEI; i.e., mean minor [G] allele frequency for sites in each cell) across six cortical Brodmann areas (BA), for inhibitory (teal) and excitatory (red) neurons. All groups except for Ex neurons in BA10 and In neurons in BA22 show significantly different GEI compared to In neurons of BA8. (B) Abundance of neuronal subgroups between cortical regions, as defined by Lake et al. (2016). Note different x-axis scales. (C) Global editing index in neuronal subgroups and when collapsed into gross neuronal phenotypes. All subgroups are significantly different to Ex1 except for Ex8 and In3. In: inhibitory neuron; Ex: excitatory neuron.
