APA events in individual cell types from individual patients. (A) Number of genes with 3′ UTR shortening inferred from patient 3 (green), patient 4 (orange), and patient 6 (purple) samples from the Lambrechts data set. (B) Number of genes with 3′ UTR lengthening, same colors as A. (C) Fraction of 3′ UTR shortening events in individual cell types, among all significant events. (D) Number of genes whose TEs undergo significant length change in quasi-bulk samples, shortening and lengthening events being shown separately. (E) Venn diagrams of significantly shortened TEs in myeloid, T, endothelial, and fibroblast cells from tumor relative to matched control samples from distinct patients. Calculation of odds ratio and P-value of overlap with hypergeometric distribution (see Materials and Methods). (F) Biological process enrichment for TEs found to be shorter in cancer compared to matched control cells of individual cell types, from patient 3 and patient 6. Plot generated with pheatmap (v 1.0.12).
