FIGURE 1.
KDM3A is a regulator of transcription and alternative splicing of cell cycle and DNA damage genes. MCF7 cells were transfected with nontargeting siRNA (siNT) and siKDM3A for 72 h. RNA was extracted, libraries prepared, and RNA-seq was conducted. (A) Venn diagram representing differentially expressed genes (blue) and alternatively spliced genes (red). (B,C) Functional analysis was conducted using the DAVID functional annotation tool (DAVID, https://david.ncifcrf.gov/) for (B) differentially expressed genes and (C) alternative splicing genes.
