SRSF10: an atypical splicing regulator with critical roles in stress response, organ development, and viral replication

Impact of temperature on SRSF10 activity and feedback regulation of SRSF10 through CLK1 splicing. SRSF10 phosphorylated residues are protected from dephosphorylation by 14-3-3 proteins while the activity of protein phosphatase 1 (PP1) is kept repressed by a complex that contains NIPP1. Upon heat-shock, PP1 dissociates from NIPP1 and SRSF10 dissociates from 14-3-3 proteins, allowing dephosphorylation of SRSF10. CLK kinases and SRPK1 will rephosphorylate SRSF10 as part of the recovery from heat-shock. Homeostatic levels of phosphorylated SRSF10 are controlled through both CLK1 and SRSF10 pre-mRNA splicing.