SRSF10: an atypical splicing regulator with critical roles in stress response, organ development, and viral replication

SRSF10 as a splicing repressor. (A) In a competitive environment, blocking splicing can shift splice site selection. When two 5′ splice sites are bound by U1 snRNP, the one that is most proximal to the 3′ splice site is used preferentially. SRSF10 binding can destabilize the interaction of U1 snRNP with 5′ splice sites to prevent splicing and therefore shift overall splicing to the distal 5′ splice site. (B) The exonic m⁶A (A^m) is bound by the reader protein YTHDC1, that in turn recruits and stabilizes SRSF3 binding to promote exon inclusion by blocking SRSF10 binding which normally promotes exon skipping.