Cover image

iMango-III fluorescent aptamer (PDB id: 6PQ7; Trachman III RJ, Stagno JR, Conrad C, Jones CP, Fischer P, Meents A, Wang YX, Ferre-D'Amare AR. 2019. Co-crystal structure of the iMango-III fluorescent RNA aptamer using an X-ray free-electron laser. Acta Cryst F 75: 547). Upon binding TO1-biotin, the iMango-III aptamer achieves the largest fluorescence enhancement reported for turn-on aptamers (over 5000-fold). RNA backbone is displayed as a red ribbon; block bases use NDB colors: A—red, C—yellow, G—green, U—cyan. TO1-biotin is shown as spheres. Cover image provided by the Nucleic Acid Database (ndbserver.rutgers.edu). Image generated using DSSR and PyMOL (Lu XJ. 2020. DSSR-enabled innovative schematics of 3D nucleic acid structures with PyMOL. Nucleic Acids Res 48: e74).