Sulfonated inhibitors of the RNA editing ligases validate the essential role of the MRP1/2 proteins in kinetoplastid RNA editing

Model representing role of the MRP1/2 heterotetramer in RNA editing. The RECC or the editosome is incapable of initiating editing and requires the RNA annealing activity of the MRP1/2 heterotetramer for presenting the “editable” RNA duplex to the catalytic complex. C35 and MrB interfere with the RNA-binding capacity of MRP1/2, and therefore interfere with the RNA editing capacity of the core complex. ES indicates editing site.