Assessing the accuracy of direct-coupling analysis for RNA contact prediction

Glycine riboswitch (PDB code 3OWI) most accurate Boltzmann learning prediction (A) and respective pseudolikelihood prediction (B). Correctly predicted contacts in secondary structure are shown in dark gray. Correctly predicted tertiary contacts are shown in light gray. We notice that the G12/C28 pair is here labeled as tertiary since it corresponds to an isolated Watson–Crick pair in the reference structure. Prediction with R-scape is shown in C.